Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 5/20 | 0.38 |
| ▸ | ACE | P12821 | 5/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.37 |
| ▸ | PSAT1 | Q9Y617 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20583260 | 0.84 | GAA (0.42) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL20583417 | 0.81 | TSHR (0.43) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL24404136 | 0.81 | TSHR (0.43) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL20583632 | 0.80 | GAA (0.43) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL24404144 | 0.77 | ALDH1A1 (0.49) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL20583689 | 0.77 | ALDH1A1 (0.49) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL24404141 | 0.77 | ALDH1A1 (0.44) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL20583296 | 0.77 | ALDH1A1 (0.44) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL20583668 | 0.76 | GAA (0.41) | GAATSHRABCC4LMNAPTGS1 | |
| SCHEMBL20583500 | 0.76 | ALDH1A1 (0.48) | GAATSHRABCC4LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| US-20200079721-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED (HK) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079721-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | DPP4, ACE, DPP8 | GAA 63/4885TSHR 3965/4885ABCC4 3539/4885 |
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | DPP4, ACE, DPP8 | GAA 63/4885TSHR 3965/4885ABCC4 3539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.