SCHEMBL21799298

SCHEMBL21799298

Oc1c(Br)cccc1-c1ccc(F)cc1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3R1 P27986 1/20 0.40
PIK3CA P42336 1/20 0.40
TTR P02766 2/20 0.38
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
USP2 O75604 1/20 0.37
ALDH1A1 P00352 1/20 0.37
DHFR P00374 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
LMNA P02545 1/20 0.37
ALB P02768 1/20 0.37
HMGB1 P09429 1/20 0.37
HPGD P15428 1/20 0.37
CXCL12 P48061 1/20 0.37
KMT2A Q03164 1/20 0.37
HIF1A Q16665 1/20 0.37
SLC22A6 Q4U2R8 1/20 0.37
ACMSD Q8TDX5 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30688744 1.00 PIK3R1 (0.40) PIK3R1PIK3CATTRKDM4EMEN1
SCHEMBL31189115 0.86 CA9 (0.41) CA1CA2LMNAHSD17B1HSD17B2
SCHEMBL30567019 0.83 SMN1; SMN2 (0.41) ALDH1A1LMNAHPGDHTR2AHTR2C
SCHEMBL26185789 0.83 SMN1; SMN2 (0.41) ALDH1A1LMNAHPGDHTR2AHTR2C
SCHEMBL17241785 0.81 MAPT (0.39) PIK3R1PIK3CAKDM4EMEN1ALDH1A1
SCHEMBL29352358 0.81 MAPT (0.39) PIK3R1PIK3CAKDM4EMEN1ALDH1A1
SCHEMBL31435745 0.81 PIK3R1 (0.43) PIK3R1PIK3CAALDH1A1GPR3
SCHEMBL1826696 0.81 PIK3R1 (0.43) PIK3R1PIK3CAALDH1A1GPR3
SCHEMBL11323890 0.78 CA1 (0.45) KDM4EMEN1ALDH1A1CA1CA2
SCHEMBL24086757 0.76 GABRA1 (0.38) PIK3R1PIK3CATTRKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250072279-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2025-02-27 US disclosed
US-12167674-B2 Metal complex with fluorine substitution Beijing Summer Sprout Technology Co., Ltd. (CN) 2024-12-10 US disclosed
EP-4098716-B1 METAL COMPLEX WITH FLUORINE SUBSTITUTION BEIJING SUMMER SPROUT TECH CO LTD (CN) 2024-08-21 EP disclosed
EP-4098716-A2 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-12-07 EP disclosed
EP-4098716-A2 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-12-07 EP disclosed
EP-3623443-B1 METAL COMPLEX WITH FLUORINE SUBSTITUTION BEIJING SUMMER SPROUT TECH CO LTD (CN) 2022-05-18 EP disclosed
US-20200091442-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2020-03-19 US disclosed
EP-3623443-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2020-03-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250072279-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION AFF4, AFF2, AFF1 PIK3R1 4676/4885PIK3CA 2835/4885TTR 2071/4885
US-12167674-B2 Metal complex with fluorine substitution AFF4, AFF2, AFF1 PIK3R1 4676/4885PIK3CA 2835/4885TTR 2071/4885
US-20200091442-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION AFF4, AFF2, AFF1 PIK3R1 4676/4885PIK3CA 2835/4885TTR 2071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.