Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | USP2 | O75604 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801377 | 0.95 | CYP1A2 (0.38) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL24345188 | 0.91 | MAPT (0.43) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21801365 | 0.90 | MAPT (0.41) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL24490646 | 0.88 | CYP1A2 (0.40) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21801583 | 0.86 | MAPT (0.40) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL24345334 | 0.86 | CYP1A2 (0.41) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21801374 | 0.85 | CYP1A2 (0.38) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL28650199 | 0.82 | CYP1A2 (0.38) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21178737 | 0.81 | RET (0.48) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21801401 | 0.81 | RET (0.37) | HSD17B10RETTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849986-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020055672-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-03-19 | — | — | WO | disclosed |