Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 5/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24345334 | 0.95 | CYP1A2 (0.41) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21801365 | 0.91 | MAPT (0.41) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21801581 | 0.91 | MAPT (0.40) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21801583 | 0.90 | MAPT (0.40) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL24490646 | 0.89 | CYP1A2 (0.40) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21801374 | 0.86 | CYP1A2 (0.38) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21801377 | 0.85 | CYP1A2 (0.38) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178737 | 0.85 | RET (0.48) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL28650199 | 0.84 | CYP1A2 (0.38) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL28655516 | 0.82 | CYP1A2 (0.39) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220112214-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112214-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, FRK | MAPT 318/4885CYP1A2 3948/4885CYP3A4 4163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.