Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801696 | 0.90 | MAPT (0.50) | MAPTHTTMAPK1TDP1MEN1 | |
| SCHEMBL21801554 | 0.89 | MAPT (0.52) | MAPTHTTTSHRMAPK1ATM | |
| SCHEMBL21801461 | 0.88 | MAPK1 (0.50) | MAPTHTTTSHRMAPK1ATM | |
| SCHEMBL21801525 | 0.88 | MAPT (0.53) | MAPTTSHRMAPK1TDP1MEN1 | |
| SCHEMBL24750370 | 0.85 | MAPT (0.46) | MAPTHTTMAPK1TDP1GSK3B | |
| SCHEMBL21801494 | 0.79 | MAPT (0.48) | MAPTHTTMAPK1TDP1MEN1 | |
| SCHEMBL21801498 | 0.79 | GSK3B (0.46) | MAPTTSHRMAPK1TDP1GSK3B | |
| SCHEMBL21801469 | 0.77 | GSK3B (0.48) | MAPTHTTTSHRMAPK1ATM | |
| SCHEMBL21801479 | 0.77 | QPCT (0.48) | MAPTTSHRMAPK1TDP1GSK3B | |
| SCHEMBL21801466 | 0.76 | MAPT (0.51) | MAPTMAPK1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220257569-A1 | INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-08-18 | — | — | US | disclosed |
| WO-2020051707-A1 | INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220257569-A1 | INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE | CNR2, GPR119, CNR1 | MAPT 2269/4885HTT 3755/4885TSHR 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.