Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 20/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.78 |
| ▸ | ATR | Q13535 | 2/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.60 |
| ▸ | MTOR | P42345 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30189149 | 1.00 | ATM (0.78) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL30189160 | 0.99 | ATM (0.79) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL20844074 | 0.99 | ATM (0.79) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL30189158 | 0.99 | ATM (0.79) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL24249983 | 0.95 | ATM (0.70) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911556 | 0.94 | ATM (0.69) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL30189175 | 0.94 | ATM (0.69) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911558 | 0.93 | ATM (0.68) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911393 | 0.93 | ATM (0.68) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911546 | 0.93 | ATM (0.68) | ATMKCNH2ATRPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220047595-A1 | 1-ISOPROPYL-3-METHYL-8-(PYRIDIN-3-YL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-c]CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2022-02-17 | — | — | US | disclosed |
| EP-3849984-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-C] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | Suzhou Zanrong Pharma Limited (CN) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020052688-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020052688-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220047595-A1 | 1-ISOPROPYL-3-METHYL-8-(PYRIDIN-3-YL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-c]CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | ATM, CHEK2, CHEK1 | ATM 1/4885KCNH2 3676/4885ATR 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.