Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 20/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.79 |
| ▸ | ATR | Q13535 | 2/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.59 |
| ▸ | MTOR | P42345 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20844074 | 1.00 | ATM (0.79) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL30189160 | 1.00 | ATM (0.79) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21802025 | 0.99 | ATM (0.78) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL30189149 | 0.99 | ATM (0.78) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL24249983 | 0.94 | ATM (0.70) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911556 | 0.94 | ATM (0.69) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL30189175 | 0.94 | ATM (0.69) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911393 | 0.92 | ATM (0.68) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911546 | 0.92 | ATM (0.68) | ATMKCNH2ATRPIK3CAMTOR | |
| SCHEMBL21911558 | 0.92 | ATM (0.68) | ATMKCNH2ATRPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115636833-B | Substituted imidazo [4,5-c ] cinnolin-2-one compounds as selective modulators of ATM kinases and uses thereof | 苏州赞荣医药科技有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-112752758-B | Imidazo [4,5-c ] cinnolin-2-one compounds as selective modulators of ATM kinase and uses thereof | 苏州赞荣医药科技有限公司 | 2023-05-23 | — | — | CN | claimed |
| CN-115636833-A | Substituted imidazo [4,5-c ] cinnolin-2-one compounds as selective modulators of ATM kinases and uses thereof | 苏州赞荣医药科技有限公司 | 2023-01-24 | — | — | CN | claimed |
| EP-4516318-A2 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-C] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | Suzhou Zanrong Pharma Limited (CN) | 2025-03-05 | — | — | EP | disclosed |
| US-12226414-B2 | 1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2025-02-18 | — | — | US | disclosed |
| CN-115636833-B | Substituted imidazo [4,5-c ] cinnolin-2-one compounds as selective modulators of ATM kinases and uses thereof | 苏州赞荣医药科技有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-112752758-B | Imidazo [4,5-c ] cinnolin-2-one compounds as selective modulators of ATM kinase and uses thereof | 苏州赞荣医药科技有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-115636833-A | Substituted imidazo [4,5-c ] cinnolin-2-one compounds as selective modulators of ATM kinases and uses thereof | 苏州赞荣医药科技有限公司 | 2023-01-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12226414-B2 | 1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof | ATM, CHEK2, CHEK1 | ATM 1/4885KCNH2 3676/4885ATR 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.