⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087066 | 0.77 | CA1 (0.39) | — | |
| SCHEMBL1306461 | 0.73 | L3MBTL1 (0.50) | — | |
| SCHEMBL11528091 | 0.73 | MAPT (0.55) | — | |
| SCHEMBL5658402 | 0.71 | — | — | |
| SCHEMBL10597056 | 0.71 | HDAC8 (0.50) | — | |
| SCHEMBL67142 | 0.71 | — | — | |
| SCHEMBL8069168 | 0.69 | — | — | |
| SCHEMBL1943624 | 0.69 | — | — | |
| SCHEMBL1003203 | 0.69 | — | — | |
| SCHEMBL2540113 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106045969-B | A kind of synthetic method of the card than replacing Buddhist nun | 湖南欧亚药业有限公司 | 2019-04-12 | — | — | CN | claimed |
| CN-106866624-B | It is a kind of to block than the chemical synthesis process for Buddhist nun | 济宁医学院 | 2017-12-26 | — | — | CN | claimed |
| CN-106866624-A | It is a kind of to block than the chemical synthesis process for Buddhist nun | 济宁医学院 | 2017-06-20 | — | — | CN | claimed |
| CN-102137847-B | Bicyclic heterocycles as MEK kinase inhibitors | GENENTECH INC | 2015-06-10 | — | — | CN | claimed |
| CN-102596951-B | Heterocyclic sulfonamide derivatives useful as MEK inhibitors | NOVARTIS AG | 2015-04-15 | — | — | CN | claimed |
| CN-101945870-B | 5-anilinoimidazopyridines and methods of use | GENENTECH INC | 2012-10-03 | — | — | CN | claimed |
| CN-104774188-B | Benzo-heterocycle or benzo hetero-aromatic ring analog derivative, preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-104892582-B | Azetidine as the mek inhibitor for treating proliferative disease | 埃克塞利希斯股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-106008487-B | A kind of talan analog derivative and preparation method thereof | 北京理工大学 | 2019-08-09 | — | — | CN | disclosed |
| CN-110036014-A | A kind of compound and its preparation and application with AXL inhibitory activity | 中国科学院上海药物研究所 | 2019-07-19 | — | — | CN | disclosed |
| CN-110012668-A | N- {3- [ 3-cyclopropyl-5- (2-fluoro-4-iodophenylamino) -6, 8-dimethyl-2, 4, 7-trioxo-3, 4,6, 7-tetrahydro-2H-pyrido [4,3-d ] pyrimidin-1-yl ] -phenyl } -cyclopropanecarboxamide dimethylsulfoxide solvate as an inhibitor of M K1/2 | R-PHARM股份公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-109988105-A | Heterocyclic nitrogen compound and preparation method thereof as kinases inhibitor | 天津滨江药物研发有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-109906224-A | TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF | 诺华股份有限公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-101035773-A | HIV inhibiting 1.2.4-triazin-6-one derivates | JANSSEN PHARMACEUTICA NV (BE) | 2007-09-12 | — | — | CN | disclosed |
| EP-1814855-A2 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006048152-A2 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | disclosed |
| CN-1195729-C | Fluorine-containing aniline compounds | NIHON NOHYAKU CO LTD (JP) | 2005-04-06 | — | — | CN | disclosed |
| EP-1467965-A1 | N-(4-SUBSTITUTED PHENYL)-ANTHRANILIC ACID HYDROXAMATE ESTERS | Warner-Lambert Company LLC (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062189-A1 | N-(4-SUBSTITUTED PHENYL)-ANTHRANILIC ACID HYDROXAMATE ESTERS | WARNER-LAMBERT COMPANY LLC (US) | 2003-07-31 | — | — | WO | disclosed |
| CN-1228413-A | Fluorine-containing aniline compounds | NIHON NOHYAKU CO LTD (JP) | 1999-09-15 | — | — | CN | disclosed |