Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786779 | 0.93 | TSHR (0.49) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL21803940 | 0.89 | TSHR (0.45) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL21804283 | 0.89 | TSHR (0.47) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL4854023 | 0.85 | TSHR (0.46) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL3261638 | 0.85 | TSHR (0.52) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL21804494 | 0.84 | TSHR (0.49) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL3721899 | 0.82 | TSHR (0.52) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL21815215 | 0.81 | CCNE2 (0.36) | TSHRKDM4EHSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL21804408 | 0.81 | TSHR (0.45) | TSHRKDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL21804713 | 0.81 | TSHR (0.45) | TSHRKDM4EHSD17B10ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113365632-B | Aminopyrimidine compounds | 卡都瑞恩医药有限公司 | 2024-03-08 | — | — | CN | disclosed |
| EP-3856188-B1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS INC (US) | 2023-06-21 | — | — | EP | disclosed |
| US-20220112184-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC | 2022-04-14 | — | — | US | disclosed |
| US-11130752-B2 | Aminopyrimidine compound | CARDURION PHARMACEUTICALS, LLC (US) | 2021-09-28 | — | — | US | disclosed |
| CN-113365632-A | Aminopyrimidine compounds | 卡都瑞恩医药有限责任公司 | 2021-09-07 | — | — | CN | disclosed |
| EP-3856188-A1 | AMINOPYRIMIDINE COMPOUND | Cardurion Pharmaceuticals, LLC (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020068854-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC (US) | 2020-04-02 | — | — | WO | disclosed |
| US-20200095240-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC | 2020-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130752-B2 | Aminopyrimidine compound | CALM1, CAMK4, CAMK2B | TSHR 2471/4885KDM4E 2694/4885HSD17B10 3741/4885 |
| US-20200095240-A1 | AMINOPYRIMIDINE COMPOUND | CALM1, CAMK4, CAMK2B | TSHR 2471/4885KDM4E 2694/4885HSD17B10 3741/4885 |
| US-20220112184-A1 | AMINOPYRIMIDINE COMPOUND | CALM1, CAMK4, CAMK2B | TSHR 2471/4885KDM4E 2694/4885HSD17B10 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.