Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21805993 | 0.69 | DYRK1A (0.41) | PIM1 | |
| SCHEMBL21805985 | 0.65 | — | — | |
| SCHEMBL28573338 | 0.60 | JAK2 (0.45) | PIM1 | |
| SCHEMBL21208806 | 0.58 | — | — | |
| SCHEMBL21861348 | 0.58 | AKT1 (0.44) | PIM1PIM3PIM2 | |
| SCHEMBL3363101 | 0.57 | HSP90AA1 (0.53) | — | |
| SCHEMBL3366129 | 0.57 | ALOX5AP (0.45) | — | |
| SCHEMBL31253225 | 0.55 | HSP90AA1 (0.49) | — | |
| SCHEMBL31253224 | 0.55 | HSP90AA1 (0.49) | — | |
| SCHEMBL21208798 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3852736-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | Metacrine, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061118-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020061117-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |