Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | F13A1 | P00488 | 2/20 | 0.44 |
| ▸ | TGM2 | P21980 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28408148 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL711419 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL2492947 | 0.93 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL15084704 | 0.93 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL1103933 | 0.93 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL3620573 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL504558 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL18592896 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL29080072 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11916703 | 0.85 | PDE4B (0.57) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853212-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF | Novartis AG (CH) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020058913-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2020-03-26 | — | — | WO | disclosed |