Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.56 |
| ▸ | ABL1 | P00519 | 7/20 | 0.56 |
| ▸ | PRKCA | P17252 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117270 | 0.85 | EGFR (0.60) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL31236246 | 0.81 | PDPK1 (0.56) | EGFRPRKCACDK1TTBK1TTBK2 | |
| SCHEMBL31236247 | 0.81 | PDPK1 (0.56) | EGFRPRKCACDK1TTBK1TTBK2 | |
| SCHEMBL6235344 | 0.80 | EGFR (0.55) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL4930240 | 0.78 | EGFR (0.52) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL4006360 | 0.76 | BRAF (0.60) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL13020445 | 0.76 | EGFR (0.50) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL4923141 | 0.75 | EGFR (0.52) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL19507722 | 0.75 | EGFR (0.49) | EGFRABL1PRKCASRCABL2 | |
| SCHEMBL6686751 | 0.75 | EGFR (0.52) | EGFRABL1PRKCASRCABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853230-A1 | CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO | Vyera Pharmaceuticals, LLC (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061279-A1 | CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO | Vyera Pharmaceuticals, LLC (US) | 2020-03-26 | — | — | WO | disclosed |