Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.52 |
| ▸ | ABL1 | P00519 | 10/20 | 0.52 |
| ▸ | PRKCA | P17252 | 7/20 | 0.52 |
| ▸ | CDK1 | P06493 | 5/20 | 0.52 |
| ▸ | SRC | P12931 | 6/20 | 0.49 |
| ▸ | ABL2 | P42684 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6682618 | 0.95 | EGFR (0.49) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL6235344 | 0.90 | EGFR (0.55) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL19507722 | 0.88 | EGFR (0.49) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL6684888 | 0.87 | EGFR (0.52) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL13861667 | 0.85 | TTBK1 (0.52) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL6684639 | 0.84 | LMNA (0.57) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL8116135 | 0.83 | EGFR (0.69) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL19507769 | 0.82 | EGFR (0.52) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL8115158 | 0.81 | EGFR (0.68) | EGFRABL1PRKCACDK1SRC | |
| SCHEMBL6689654 | 0.79 | FGFR1 (0.57) | EGFRABL1PRKCACDK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832092-B1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0832091-B1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR INC (US) | 2004-01-14 | — | — | EP | disclosed |