Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL21807344 | 1.00 | CA4 (0.65) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL60075 | 0.98 | CA4 (0.61) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL25267224 | 0.98 | CA4 (0.61) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL30809599 | 0.92 | CA4 (0.59) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Gluconic Acid SCHEMBL9004051 | 0.90 | PDE4A (0.59) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL8578020 | 0.90 | LMNA (0.66) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL10438269 | 0.90 | LMNA (0.65) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL873958 | 0.89 | CA4 (0.52) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Citric Acid SCHEMBL28000818 | 0.89 | CA4 (0.52) | CA4LMNAL3MBTL1TDP1PDE4A | |
| Gluconic Acid SCHEMBL27319696 | 0.89 | LMNA (0.64) | CA4LMNAL3MBTL1TDP1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220204450-A1 | Orally Active Melanocortin Receptor-4 Compounds | PALATIN TECHNOLOGIES, INC. (US) | 2022-06-30 | — | — | US | disclosed |
| US-20210198201-A1 | Orally Active Melanocortin Receptor-4 Compounds | PALATIN TECHNOLOGIES INC (US) | 2021-07-01 | — | — | US | disclosed |
| WO-2020060983-A2 | ORALLY ACTIVE MELANOCORTIN RECEPTOR-4 COMPOUNDS | PALATIN TECHNOLOGIES, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198201-A1 | Orally Active Melanocortin Receptor-4 Compounds | MC4R, MC1R, MC3R | CA4 2992/4885LMNA 4226/4885L3MBTL1 987/4885 |
| US-20220204450-A1 | Orally Active Melanocortin Receptor-4 Compounds | MC4R, MC1R, MC3R | CA4 2992/4885LMNA 4226/4885L3MBTL1 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.