SCHEMBL21815367

SCHEMBL21815367

Clc1ncc(N2CCNCC2)cn1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 10/20 0.59
CHRNA4 P43681 10/20 0.59
ADRB1 P08588 5/20 0.53
HTR3E A5X5Y0 3/20 0.53
HTR3B O95264 3/20 0.53
HTR3A P46098 3/20 0.53
HTR3D Q70Z44 3/20 0.53
HTR3C Q8WXA8 3/20 0.53
SIGMAR1 Q99720 3/20 0.53
CHRM2 P08172 1/20 0.53
CHRM4 P08173 1/20 0.53
CHRM1 P11229 1/20 0.53
CHRM3 P20309 1/20 0.53
ADRB2 P07550 2/20 0.50
CHRNA1 P02708 1/20 0.49
CHRNA7 P36544 1/20 0.49
NCF1 P14598 1/20 0.48
PLD1 Q13393 1/20 0.48
TP53 P04637 1/20 0.47
CYP1A2 P05177 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25260546 0.79 CHRNB2 (0.55) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL18291422 0.79 CHRNB2 (0.55) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL17770393 0.79 CHRNB2 (0.55) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL16892077 0.79 CHRNB2 (0.55) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL20311310 0.79 CHRNB2 (0.59) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL2923088 0.79 CHRNB2 (0.64) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL27493510 0.78 MAPT (0.44) CHRNB2CHRNA4TP53CYP1A2THRB
Hydrochloric Acid SCHEMBL3069993 0.77 CHRNB2 (0.62) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL3068345 0.77 CHRNB2 (0.71) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL29731531 0.76 KDM4E (0.55) CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856737-A1 HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2021-08-04 EP disclosed
WO-2020064792-A1 HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2020-04-02 WO disclosed