Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 15/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182022 | 0.90 | GRIA2 (0.71) | GRIA2ALDH1A1HPGDSMN1; SMN2GRIA1 | |
| SCHEMBL2178746 | 0.78 | GRIA2 (0.58) | GRIA2GRIA1GRIA3GRIA4MMP13 | |
| SCHEMBL2161137 | 0.78 | GRIA2 (0.62) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2183670 | 0.77 | GRIA2 (0.58) | GRIA2ALDH1A1HPGDSMN1; SMN2GRIA1 | |
| SCHEMBL2152080 | 0.74 | GRIA2 (1.00) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2183726 | 0.74 | GRIA2 (0.77) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5620058 | 0.73 | GRIA2 (0.41) | GRIA2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2152051 | 0.72 | GRIA2 (1.00) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5621550 | 0.71 | GRIA2 (0.39) | GRIA2ALDH1A1HPGD | |
| SCHEMBL2179977 | 0.71 | GRIA2 (1.00) | GRIA2GRIA1GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083265-A1 | NOVEL DERIVATIVES OF CYCLOPROPYLATED BENZOTHIADIAZINES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2011-07-14 | — | — | WO | disclosed |