Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16985343 | 1.00 | LRRK2 (0.46) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL21850239 | 0.88 | LRRK2 (0.36) | LRRK2DYRK1A | |
| SCHEMBL16985357 | 0.85 | LRRK2 (0.53) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL16985407 | 0.85 | LRRK2 (0.53) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL21958372 | 0.85 | LRRK2 (0.46) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL16985433 | 0.85 | LRRK2 (0.53) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL21859053 | 0.85 | LRRK2 (0.46) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL16975542 | 0.85 | LRRK2 (0.53) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL16985418 | 0.85 | LRRK2 (0.44) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 | |
| SCHEMBL16975552 | 0.85 | LRRK2 (0.44) | LRRK2DYRK1AKCNH2KAT2BMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099695-B1 | COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-04-08 | — | — | EP | disclosed |