Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 2/20 | 0.58 |
| ▸ | CCR2 | P41597 | 5/20 | 0.52 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31689701 | 1.00 | CCR9 (0.58) | CCR9CCR2PLA2G10PLA2G2AALDH1A1 | |
| SCHEMBL21822198 | 0.85 | TSHR (0.53) | CCR9PLA2G10PLA2G2AALDH1A1POLB | |
| SCHEMBL1422436 | 0.82 | CCR2 (0.74) | CCR2PLA2G10ALDH1A1CYP1A2POLB | |
| SCHEMBL31689681 | 0.81 | CCR9 (0.52) | CCR9CCR2PLA2G10PLA2G2AALDH1A1 | |
| SCHEMBL21822478 | 0.81 | CCR9 (0.52) | CCR9CCR2PLA2G10PLA2G2AALDH1A1 | |
| SCHEMBL21822281 | 0.81 | CCR9 (0.69) | CCR9CCR2GPR35 | |
| SCHEMBL31689688 | 0.81 | CCR9 (0.69) | CCR9CCR2GPR35 | |
| SCHEMBL28593764 | 0.81 | CCR9 (0.72) | CCR9CCR2GPR35 | |
| SCHEMBL21822343 | 0.80 | F10 (0.49) | CCR9PLA2G10PLA2G2AALDH1A1POLB | |
| SCHEMBL10022666 | 0.80 | CCR9 (0.65) | CCR9CCR2PLA2G10PLA2G2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |