Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 8/20 | 0.43 |
| ▸ | F2 | P00734 | 6/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28573746 | 0.92 | KDM4E (0.51) | KDM4EPKMF10F2PRSS1 | |
| SCHEMBL21823023 | 0.89 | F10 (0.55) | KDM4EPKMF10F2PRSS1 | |
| SCHEMBL21822837 | 0.84 | F10 (0.39) | F10F2PRSS1BCHEMAOB | |
| SCHEMBL21822651 | 0.83 | KDM4E (0.51) | KDM4EPKMF10TP53LMNA | |
| SCHEMBL28588834 | 0.82 | F10 (0.43) | F10F2PRSS1 | |
| SCHEMBL28588833 | 0.82 | F10 (0.43) | F10F2PRSS1 | |
| SCHEMBL30180747 | 0.82 | F10 (0.43) | F10F2PRSS1 | |
| SCHEMBL25017546 | 0.76 | F10 (0.43) | F10F2PRSS1BRD4BCHE | |
| SCHEMBL21822470 | 0.76 | F10 (0.43) | F10F2PRSS1BRD4BCHE | |
| SCHEMBL21822469 | 0.76 | F10 (0.43) | F10F2PRSS1BRD4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-B1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE INC (US) | 2026-01-28 | — | — | EP | disclosed |
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |