Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 7/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.51 |
| ▸ | PLG | P00747 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28573746 | 0.91 | KDM4E (0.51) | F10KDM4EPKMF2PRSS1 | |
| SCHEMBL21822834 | 0.89 | KDM4E (0.49) | F10KDM4EPKMF2PRSS1 | |
| SCHEMBL21822651 | 0.86 | KDM4E (0.51) | F10KDM4EPKMTP53 | |
| SCHEMBL21822628 | 0.83 | F10 (0.55) | F10F2PRSS1 | |
| SCHEMBL25016738 | 0.81 | F10 (0.49) | F10F2PRSS1 | |
| SCHEMBL28585736 | 0.81 | F10 (0.49) | F10F2PRSS1 | |
| SCHEMBL25015770 | 0.80 | KDM4E (0.49) | F10KDM4EPKMTP53 | |
| SCHEMBL10144835 | 0.78 | KDM4E (0.76) | KDM4EPKM | |
| SCHEMBL25015873 | 0.78 | F10 (0.51) | F10F2PRSS1PLGTPSAB1 | |
| SCHEMBL25017879 | 0.78 | F10 (0.53) | F10F2PRSS1PLGPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |