⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28120110 | 1.00 | — | — | |
| SCHEMBL27897433 | 1.00 | — | — | |
| SCHEMBL1029275 | 0.74 | — | — | |
| SCHEMBL7570227 | 0.74 | — | — | |
| SCHEMBL215173 | 0.73 | — | — | |
| SCHEMBL11423875 | 0.73 | — | — | |
| SCHEMBL14157902 | 0.69 | LMNA (0.38) | — | |
| SCHEMBL2063176 | 0.69 | — | — | |
| SCHEMBL3608 | 0.69 | — | — | |
| SCHEMBL5245179 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103249424-B | For treating and preventing the novel cyclosporin derivatives of virus infection | 河北鲲翔济世医药科技有限公司 | 2016-08-10 | — | — | CN | claimed |
| CN-114007671-B | Methods and compositions for treating chronic inflammatory lesions, metaplasias, dysplasias, and cancers of epithelial tissue | 休斯敦大学体系 | 2024-06-14 | — | — | CN | disclosed |
| CN-116874485-B | Preparation and application of spiro compound with blood pressure reducing effect | 山东如至生物医药科技有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117986237-A | Ligustrazine derivative and preparation method and application thereof | 南京知和医药科技有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-116874485-A | Preparation and application of spiro compound with blood pressure reducing effect | 山东如至生物医药科技有限公司 | 2023-10-13 | — | — | CN | disclosed |
| US-20220202792-A1 | METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2022-06-30 | — | — | US | disclosed |
| EP-3962559-A1 | METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES | University of Houston System (US) | 2022-03-09 | — | — | EP | disclosed |
| CN-114007671-A | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancer of epithelial tissue | 休斯敦大学体系 | 2022-02-01 | — | — | CN | disclosed |
| CN-108329246-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2021-02-26 | — | — | CN | disclosed |
| US-10889589-B2 | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | ARRAY BIOPHARMA INC. (US) | 2021-01-12 | — | — | US | disclosed |
| EP-0009191-A1 | Water-insoluble disazodyestuffs, their preparation and application | CASSELLA Aktiengesellschaft (DE) | 1980-04-02 | — | — | EP | disclosed |
| US-4171356-A | 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor | SCHERING CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4085208-A | Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor | SCHERING CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4062947-A | Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor | SCHERING CORPORATION (US) | 1977-12-13 | — | — | US | disclosed |
| US-4053591-A | 5-DEOXY-4,6-DI-O-(AMINOGLYCOSYL)-1,3-DIAMINOCYCLITOLS, METHODS FOR THEIR MANUFACTURE, METHOD FOR THEIR USE AS ANTIBACTERIAL AGENTS AND COMPOSITIONS USEFUL THEREFOR | SCHERING CORPORATION (US) | 1977-10-11 | — | — | US | disclosed |
| US-4044123-A | ANTIBIOTICS | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |
| US-4002608-A | ANTIBACTERIALS | SCHERING CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |
| US-4002742-A | 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor | SCHERING CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |
| US-4000262-A | 5-EPI-AMINO AND 5-EPI-AZIDO-4,6-DI-O-(AMINOGLYCOSYL)-2,5-DIDEOXYSTREPTAMINES 1-N-ALKYL-5-EPI-AMINO AND 1-N-ALKYL-5-EPI-AZIDO-4,6-DI-O-(AMINOGLYCOSYL)-2,5-DIDEOXYSTREPTAMINES | SCHERING CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000261-A | 5-EPI-4,6-DI-O-(AMINOGLYCOSYL)-2-DEOXYSTREPTAMINES, METHODS FOR THEIR MANUFACTURE AND INTERMEDIATES USEFUL THEREIN, METHODS FOR THEIR USE AS ANTIBACTERIAL AGENTS AND COMPOSITIONS USEFUL THEREFOR | SCHERING CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |