Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19688326 | 0.90 | ELANE (0.46) | ELANECTSK | |
| SCHEMBL19639828 | 0.88 | ELANE (0.44) | ELANECTSK | |
| SCHEMBL17819346 | 0.88 | ELANE (0.51) | ELANECTSKCYP2C9MEN1KMT2A | |
| SCHEMBL17819329 | 0.87 | ELANE (0.50) | ELANECTSKCYP2C9MEN1KMT2A | |
| SCHEMBL17819304 | 0.85 | ELANE (0.62) | ELANECTSKCYP2C9MEN1KMT2A | |
| Benzene SCHEMBL19639783 | 0.83 | ELANE (0.47) | ELANECYP2C9CYP3A4 | |
| Benzene SCHEMBL19639826 | 0.82 | ELANE (0.46) | ELANECYP2C9 | |
| SCHEMBL19639791 | 0.82 | ELANE (0.46) | ELANECTSKCYP2C9CYP3A4 | |
| SCHEMBL19639767 | 0.82 | ELANE (0.47) | ELANECYP2C9CYP3A4 | |
| SCHEMBL19639749 | 0.81 | ELANE (0.47) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464269-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF A HNE RELATED DISEASE | CHIESI FARM SPA (IT) | 2020-04-01 | — | — | EP | disclosed |