SCHEMBL21834568

SCHEMBL21834568

CC(C)(C)OC(=O)N1CCC[C@H](C(=O)CBr)C1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.70
ALDH1A1 P00352 1/20 0.70
MAPT P10636 1/20 0.70
KMT2A Q03164 1/20 0.70
HPGD P15428 1/20 0.54
GLS O94925 2/20 0.45
EPHX1 P07099 1/20 0.45
RECQL P46063 1/20 0.42
BACE1 P56817 2/20 0.41
NR1H2 P55055 1/20 0.41
CTSD P07339 1/20 0.41
HSD17B10 Q99714 1/20 0.41
ABL1 P00519 1/20 0.41
RIN1 Q13671 1/20 0.41
HSD11B1 P28845 1/20 0.41
PREP P48147 1/20 0.40
USP30 Q70CQ3 1/20 0.40
USP2 O75604 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ACKR3 P25106 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2219466 1.00 MEN1 (0.70) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL2282810 0.91 KMT2A (0.58) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL23727536 0.89 HPGD (0.61) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL30382744 0.89 HPGD (0.61) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL28949458 0.87 ALDH1A1 (0.71) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL13764217 0.86 ALDH1A1 (0.70) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL27619423 0.86 MEN1 (0.70) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL15972441 0.85 NR1H2 (0.51) MEN1ALDH1A1MAPTKMT2AHPGD
Hydrochloric Acid SCHEMBL30923198 0.84 MEN1 (0.68) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL8236284 0.84 ALDH1A1 (0.68) MEN1ALDH1A1MAPTKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4366834-A1 COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS Biogen MA Inc. (US) 2024-05-15 EP disclosed
WO-2023283372-A1 COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS BIOGEN MA INC. (US) 2023-01-12 WO disclosed
WO-2020064175-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION ANTABIO SAS (FR) 2020-04-02 WO disclosed