Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.79 |
| ▸ | CASP1 | P29466 | 2/20 | 0.79 |
| ▸ | CASP7 | P55210 | 2/20 | 0.79 |
| ▸ | POLR1A | O95602 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18631335 | 0.88 | KDM4E (1.00) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL17117513 | 0.85 | POLR1A (0.64) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL21798882 | 0.82 | KDM4E (0.73) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL5775612 | 0.81 | KDM4E (0.51) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL28665936 | 0.76 | KDM4E (0.64) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL21798925 | 0.76 | POLR1A (0.47) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL29646595 | 0.75 | KDM4E (0.75) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL17099654 | 0.75 | KDM4E (0.75) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL21798918 | 0.74 | POLR1A (0.61) | KDM4EHSD17B10CASP1CASP7POLR1A | |
| SCHEMBL21798889 | 0.74 | POLR1A (0.61) | KDM4EHSD17B10CASP1CASP7POLR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111247143-B | Pyridoquinazoline derivatives useful as inhibitors of protein kinases | 昂科斯特拉公司 | 2022-07-05 | — | — | CN | disclosed |
| US-11021479-B2 | Pyridoquinazoline derivatives useful as protein kinase inhibitors | ONCOSTELLAE, S.L. (ES) | 2021-06-01 | — | — | US | disclosed |
| EP-3632912-B1 | PYRIDOQUINAZOLINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | ONCOSTELLAE S L (ES) | 2021-03-17 | — | — | EP | disclosed |
| US-20200148676-A1 | PYRIDOQUINAZOLINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | ONCOSTELLAE, S.L. (ES) | 2020-05-14 | — | — | US | disclosed |
| EP-3632912-A1 | PYRIDOQUINAZOLINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | Oncostellae, S.L. (ES) | 2020-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148676-A1 | PYRIDOQUINAZOLINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | MAP4K2, MAP4K1, MAP4K3 | KDM4E 1078/4885HSD17B10 4415/4885CASP1 1565/4885 |
| US-11021479-B2 | Pyridoquinazoline derivatives useful as protein kinase inhibitors | MAP4K2, MAP4K1, MAP4K3 | KDM4E 1078/4885HSD17B10 4415/4885CASP1 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.