Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830508 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL20762021 | 0.98 | KEAP1 (0.53) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL1447319 | 0.92 | KEAP1 (0.55) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL1830035 | 0.87 | HRH3 (0.47) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL2204107 | 0.87 | HRH3 (0.47) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL1834141 | 0.87 | HRH3 (0.47) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL426048 | 0.84 | MEN1 (0.51) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL4018004 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL4016268 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1HRH3CA1CA2 | |
| SCHEMBL4021823 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1HRH3CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342181-A1 | NOVEL UREA AND THIOUREA DERIVATIVES | Topo Target A/S (DK) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010066709-A1 | NOVEL PYRIDINYL ACRYLAMIDE DERIVATIVES | TOPOTARGET A/S (DK) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010023307-A1 | NOVEL UREA AND THIOUREA DERIVATIVES | TOPOTARGET A/S (DK) | 2010-03-04 | — | — | WO | disclosed |