Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 14/20 | 0.52 |
| ▸ | PTPRA | P18433 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1731562 | 1.00 | PTPN1 (0.52) | PTPN1PTPRAMEN1ALDH1A1HPGD | |
| SCHEMBL1731564 | 1.00 | PTPN1 (0.52) | PTPN1PTPRAMEN1ALDH1A1HPGD | |
| SCHEMBL1732507 | 0.93 | SRC (0.47) | PTPN1PTPRAPTPN2CTSSCTSK | |
| SCHEMBL1730696 | 0.93 | SRC (0.47) | PTPN1PTPRAPTPN2CTSSCTSK | |
| SCHEMBL1732891 | 0.93 | PTPN1 (0.50) | PTPN1PTPRAMEN1ALDH1A1HPGD | |
| SCHEMBL2186575 | 0.93 | PTPN1 (0.50) | PTPN1PTPRAMEN1ALDH1A1HPGD | |
| SCHEMBL1732660 | 0.93 | PTPN1 (0.50) | PTPN1PTPRAMEN1ALDH1A1HPGD | |
| SCHEMBL5893349 | 0.89 | PTPN1 (0.57) | PTPN1PTPRACTSSCTSK | |
| SCHEMBL1731310 | 0.88 | PTPN1 (0.49) | PTPN1PTPRAMEN1ALDH1A1HPGD | |
| SCHEMBL1731312 | 0.88 | PTPN1 (0.49) | PTPN1PTPRAMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341049-A1 | 5-substituted 1,1-dioxo-[1,2,5]thiazolidine-3-one derivatives as PTPASE 1B inhibitors | Novartis AG (CH) | 2011-07-06 | — | — | EP | disclosed |