Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.85 |
| ▸ | RET | P07949 | 3/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.64 |
| ▸ | CHUK | O15111 | 1/20 | 0.64 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | RAF1 | P04049 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | BCR | P11274 | 1/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.64 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.64 |
| ▸ | AXL | P30530 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21843606 | 0.93 | SRC (0.76) | SRCRETIKBKBCHUKMAP3K7 | |
| SCHEMBL17935969 | 0.92 | SRC (1.00) | SRCIKBKBCHUKMAP3K7JAK2 | |
| SCHEMBL21843541 | 0.89 | RET (0.71) | SRCRETABL1FGFR1KDR | |
| SCHEMBL17935960 | 0.88 | SRC (1.00) | SRCIKBKBCHUKMAP3K7JAK2 | |
| SCHEMBL21843547 | 0.87 | RET (0.76) | SRCRETIKBKBCHUKMAP3K7 | |
| SCHEMBL17935967 | 0.87 | SRC (1.00) | SRCIKBKBCHUKMAP3K7JAK2 | |
| SCHEMBL17936060 | 0.86 | SRC (1.00) | SRCIKBKBCHUKMAP3K7JAK2 | |
| SCHEMBL21843544 | 0.84 | RET (0.74) | SRCRETABL1EGFRFGFR1 | |
| SCHEMBL31036576 | 0.84 | RET (1.00) | RETABL1EGFRFGFR1BRAF | |
| SCHEMBL17936076 | 0.82 | SRC (1.00) | SRCIKBKBCHUKMAP3K7JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089599-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | PURDUE RESEARCH FOUNDATION | 2022-03-24 | — | — | US | disclosed |
| WO-2020053812-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089599-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | NADK, NAMPT, NME2 | SRC 271/4885RET 183/4885IKBKB 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.