Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.73 |
| ▸ | RET | P07949 | 4/20 | 0.66 |
| ▸ | ABL2 | P42684 | 3/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.66 |
| ▸ | KDR | P35968 | 3/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.66 |
| ▸ | CCDC6 | Q16204 | 2/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | MLNR | O43193 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31474784 | 0.92 | ABL1 (0.85) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL24283388 | 0.92 | ABL1 (0.77) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL21843568 | 0.92 | ABL1 (0.85) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL21843637 | 0.92 | ABL1 (0.75) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL21843529 | 0.92 | ABL1 (0.75) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL21843567 | 0.91 | ABL1 (0.74) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL24283220 | 0.91 | ABL1 (0.74) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL24283386 | 0.90 | ABL1 (0.76) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL21843533 | 0.90 | ABL1 (0.81) | ABL1RETABL2FGFR1KDR | |
| SCHEMBL21843569 | 0.90 | ABL1 (0.73) | ABL1RETABL2FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089599-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | PURDUE RESEARCH FOUNDATION | 2022-03-24 | — | — | US | disclosed |
| WO-2020053812-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089599-A1 | ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS | NADK, NAMPT, NME2 | ABL1 22/4885RET 183/4885ABL2 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.