Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 11/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | CDC42 | P60953 | 1/20 | 0.42 |
| ▸ | RAC1 | P63000 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492745 | 0.80 | AKR1C3 (0.67) | AKR1C3AKR1C2PTGS1ALDH1A1F2 | |
| Hydrochloric Acid SCHEMBL2698899 | 0.79 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS1ALDH1A1F2 | |
| SCHEMBL20616575 | 0.75 | ALDH1A1 (0.54) | AKR1C3AKR1C2PTGS1ALDH1A1F2 | |
| SCHEMBL1492713 | 0.75 | ALDH1A1 (0.49) | AKR1C3AKR1C2PTGS1ALDH1A1F2 | |
| SCHEMBL2847001 | 0.74 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL10283506 | 0.74 | ALDH1A1 (0.52) | AKR1C3AKR1C2PTGS1ALDH1A1F2 | |
| SCHEMBL19514121 | 0.73 | ALDH1A1 (0.51) | AKR1C3AKR1C2PTGS1ALDH1A1F2 | |
| SCHEMBL2699626 | 0.72 | ALDH1A1 (0.55) | AKR1C3AKR1C2ALDH1A1F2GLA | |
| SCHEMBL12181867 | 0.71 | ALDH1A1 (0.57) | AKR1C3AKR1C2PTGS1AKR1C1ALDH1A1 | |
| SCHEMBL18371227 | 0.71 | KDM4E (0.63) | ALDH1A1F2GLAHPGDPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | AKR1C3 4490/4885AKR1C2 4506/4885PTGS1 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.