Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183470 | 0.97 | CHEK2 (0.35) | HSP90AA1CHEK2PARP1AMY1A | |
| SCHEMBL2185332 | 0.94 | HSP90AA1 (0.40) | HSP90AA1CHEK2PARP1AMY1AFLT3 | |
| SCHEMBL2183548 | 0.90 | HSP90AA1 (0.36) | HSP90AA1CHEK2PARP1AMY1A | |
| SCHEMBL2185287 | 0.90 | CHEK2 (0.38) | HSP90AA1CHEK2PARP1AMY1A | |
| SCHEMBL2182172 | 0.89 | AMY1A (0.38) | HSP90AA1CHEK2PARP1AMY1AFLT3 | |
| SCHEMBL2181415 | 0.89 | CHEK2 (0.37) | HSP90AA1CHEK2PARP1AMY1AFLT3 | |
| SCHEMBL2179755 | 0.87 | CHEK2 (0.38) | CHEK2PARP1AMY1AFLT3 | |
| SCHEMBL2184560 | 0.87 | CHEK2 (0.38) | CHEK2PARP1AMY1AFLT3 | |
| SCHEMBL2183551 | 0.87 | CHEK2 (0.37) | CHEK2PARP1AMY1AFLT3 | |
| SCHEMBL12411905 | 0.86 | HSP90AA1 (0.36) | HSP90AA1CHEK2PARP1AMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166169-A1 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI-AVENTIS (FR) | 2011-07-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166169-A1 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885CHEK2 2483/4885PARP1 4296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.