Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.40 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21895551 | 0.85 | KRAS (0.33) | KRAS | |
| SCHEMBL25020057 | 0.77 | KRAS (0.41) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL22087714 | 0.74 | KRAS (0.47) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21846279 | 0.74 | KRAS (0.36) | KRAS | |
| SCHEMBL22087721 | 0.73 | KRAS (0.42) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL22087711 | 0.72 | KRAS (0.34) | KRAS | |
| SCHEMBL19637410 | 0.72 | KRAS (0.37) | KRAS | |
| SCHEMBL24321978 | 0.70 | KRAS (0.39) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL22994735 | 0.70 | KRAS (0.51) | KRAS | |
| SCHEMBL25699421 | 0.69 | KRAS (0.44) | KRASVHLCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055760-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |