Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 9/20 | 0.33 |
| ▸ | DRD2 | P14416 | 8/20 | 0.33 |
| ▸ | HTR2A | P28223 | 8/20 | 0.33 |
| ▸ | HTR1A | P08908 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21846371 | 0.85 | KRAS (0.40) | KRAS | |
| SCHEMBL21846279 | 0.83 | KRAS (0.36) | KRAS | |
| SCHEMBL19637410 | 0.82 | KRAS (0.37) | KRASDRD2HTR2AHTR1AKCNH2 | |
| SCHEMBL22087711 | 0.76 | KRAS (0.34) | KRAS | |
| SCHEMBL22087714 | 0.73 | KRAS (0.47) | KRAS | |
| SCHEMBL22994735 | 0.71 | KRAS (0.51) | KRAS | |
| SCHEMBL21846368 | 0.69 | KRAS (0.58) | KRAS | |
| SCHEMBL21895552 | 0.67 | KRAS (0.32) | KRAS | |
| SCHEMBL19637424 | 0.66 | KRAS (0.45) | KRAS | |
| SCHEMBL22994794 | 0.65 | KRAS (0.59) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |