Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | DTYMK | P23919 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13502699 | 0.82 | MAPK1 (0.42) | MAPK1POLBGPR119IDH1 | |
| SCHEMBL15467107 | 0.80 | POLB (0.44) | MAPK1POLBGPR119DTYMKDDB1 | |
| SCHEMBL21847688 | 0.78 | PIK3CA (0.40) | MAPK1GPR119DDB1CRBNGRM5 | |
| SCHEMBL21847679 | 0.77 | ESR2 (0.40) | MAPK1GPR119DDB1CRBNPIK3CA | |
| SCHEMBL29226277 | 0.77 | PIK3CA (0.39) | MAPK1GPR119DDB1CRBNNAMPT | |
| SCHEMBL23771943 | 0.77 | KDM4E (0.51) | MAPK1NAMPTPIK3CAMTOR | |
| SCHEMBL29814717 | 0.77 | KDM4E (0.51) | MAPK1NAMPTPIK3CAMTOR | |
| SCHEMBL3232990 | 0.76 | POLB (0.43) | MAPK1POLBGPR119DTYMKMAPT | |
| SCHEMBL21847682 | 0.75 | PIK3CA (0.38) | MAPK1DDB1CRBNNAMPTPIK3CA | |
| SCHEMBL29226367 | 0.75 | PIK3CA (0.38) | MAPK1GPR119DDB1CRBNPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | PFIZER INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | CHRM1, CHRM5, CHRM2 | MAPK1 1253/4885POLB 1809/4885GPR119 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.