Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21847840 | 0.85 | CHRM4 (0.55) | C5AR1CHRM4CHRM2CYP1A2MKNK1 | |
| SCHEMBL31644535 | 0.83 | C5AR1 (0.44) | C5AR1CHRM4CYP1A2MKNK1PARP1 | |
| SCHEMBL31581514 | 0.83 | C5AR1 (0.44) | C5AR1CHRM4CYP1A2MKNK1PARP1 | |
| SCHEMBL23199117 | 0.82 | C5AR1 (0.42) | C5AR1CHRM4CYP1A2MKNK1EHMT2 | |
| SCHEMBL21847923 | 0.82 | CHRM4 (0.43) | C5AR1CHRM4CYP1A2MKNK1EHMT2 | |
| SCHEMBL23199026 | 0.82 | C5AR1 (0.43) | C5AR1CHRM4CYP1A2MKNK1EHMT2 | |
| SCHEMBL21847070 | 0.81 | C5AR1 (0.43) | C5AR1CHRM4CHRM2CYP1A2MKNK1 | |
| SCHEMBL23199082 | 0.81 | C5AR1 (0.43) | C5AR1CHRM4CYP1A2MKNK1EHMT2 | |
| SCHEMBL21847888 | 0.81 | C5AR1 (0.45) | C5AR1CHRM4CYP1A2MKNK1PARP1 | |
| SCHEMBL21847924 | 0.80 | C5AR1 (0.42) | C5AR1CHRM4CHRM2CYP1A2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260055116-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | KARUNA THERAPEUTICS INC (US) | 2026-02-26 | — | — | US | disclosed |
| US-12421242-B2 | Substituted tetrahydropyrrolo-pyridinone compounds and their use in treating medical conditions | Karuna Therapeutics, Inc. (US) | 2025-09-23 | — | — | US | disclosed |
| WO-2025131049-A1 | DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES AND USES THEREOF | IGNIS THERAPEUTICS (SUZHOU) LIMITED (CN) | 2025-06-26 | — | — | WO | disclosed |
| US-20240336619-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. | 2024-10-10 | — | — | US | disclosed |
| WO-2024130064-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2024-06-20 | — | — | WO | disclosed |
| WO-2024130066-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2024-06-20 | — | — | WO | disclosed |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20210309659-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3478679-B1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES | PFIZER (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20200207762-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2020-07-02 | — | — | US | disclosed |
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | PFIZER INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309659-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | C5AR1 3218/4885CHRM4 4/4885CHRM2 3/4885 |
| US-20200207762-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | C5AR1 3218/4885CHRM4 4/4885CHRM2 3/4885 |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | C5AR1 3218/4885CHRM4 4/4885CHRM2 3/4885 |
| US-20240336619-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | CHRM3, CHRM4, CHRM2 | C5AR1 632/4885CHRM4 2/4885CHRM2 3/4885 |
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | CHRM1, CHRM5, CHRM2 | C5AR1 3218/4885CHRM4 4/4885CHRM2 3/4885 |
| US-12421242-B2 | Substituted tetrahydropyrrolo-pyridinone compounds and their use in treating medical conditions | CHRM3, CHRM4, CHRM2 | C5AR1 632/4885CHRM4 2/4885CHRM2 3/4885 |
| US-20260055116-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | CHRM3, CHRM2, CHRM1 | C5AR1 422/4885CHRM4 6/4885CHRM2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.