Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 16/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31581514 | 0.86 | C5AR1 (0.44) | CHRM4CYP1A2C5AR1MKNK1PARP1 | |
| SCHEMBL31644535 | 0.86 | C5AR1 (0.44) | CHRM4CYP1A2C5AR1MKNK1PARP1 | |
| SCHEMBL21847835 | 0.85 | C5AR1 (0.43) | CHRM4CYP1A2C5AR1CHRM2MKNK1 | |
| SCHEMBL21847923 | 0.85 | CHRM4 (0.43) | CHRM4CYP1A2C5AR1MKNK1PARP1 | |
| SCHEMBL23199026 | 0.85 | C5AR1 (0.43) | CHRM4CYP1A2C5AR1MKNK1GPR119 | |
| SCHEMBL21847853 | 0.85 | CHRM4 (0.68) | CHRM4CYP1A2CHRM2 | |
| SCHEMBL23199082 | 0.84 | C5AR1 (0.43) | CHRM4CYP1A2C5AR1MKNK1PARP1 | |
| SCHEMBL21847888 | 0.84 | C5AR1 (0.45) | CHRM4CYP1A2C5AR1MKNK1PARP1 | |
| SCHEMBL23199117 | 0.83 | C5AR1 (0.42) | CHRM4CYP1A2C5AR1MKNK1GPR119 | |
| SCHEMBL21847924 | 0.83 | C5AR1 (0.42) | CHRM4CYP1A2C5AR1CHRM2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309659-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3478679-B1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES | PFIZER (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-3478679-B1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES | PFIZER (US) | 2021-04-21 | — | — | EP | disclosed |
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | PFIZER INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309659-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | CHRM4 4/4885CYP1A2 85/4885C5AR1 3218/4885 |
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | CHRM1, CHRM5, CHRM2 | CHRM4 4/4885CYP1A2 85/4885C5AR1 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.