Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28200582 | 0.92 | GPR119 (0.60) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL4827630 | 0.92 | GPR119 (0.60) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL28856276 | 0.92 | GPR119 (0.60) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL31696351 | 0.91 | EIF2AK4 (0.49) | GPR119CHRM4PDE10ACHRM2RAB9A | |
| SCHEMBL26657916 | 0.91 | EIF2AK4 (0.49) | GPR119CHRM4PDE10ACHRM2RAB9A | |
| SCHEMBL23497763 | 0.90 | GPR119 (0.48) | GPR119CHRM4PDE10ACHRM2RAB9A | |
| SCHEMBL22775604 | 0.90 | GPR119 (0.55) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL29576568 | 0.90 | GPR119 (0.55) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL22774285 | 0.90 | GPR119 (0.55) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL29576692 | 0.90 | GPR119 (0.55) | GPR119PDE10ACKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11905284-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | PFIZER INC. (US) | 2024-02-20 | — | — | US | disclosed |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20210309659-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3478679-B1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES | PFIZER (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20200207762-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2020-07-02 | — | — | US | disclosed |
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | PFIZER INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309659-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | GPR119 1173/4885CHRM4 4/4885PDE10A 654/4885 |
| US-20200207762-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | GPR119 1173/4885CHRM4 4/4885PDE10A 654/4885 |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | GPR119 1173/4885CHRM4 4/4885PDE10A 654/4885 |
| US-10604519-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | CHRM1, CHRM5, CHRM2 | GPR119 1173/4885CHRM4 4/4885PDE10A 654/4885 |
| US-11905284-B2 | 5,7-dihydro-pyrrolo-pyridine derivatives | CHRM1, CHRM5, CHRM2 | GPR119 1173/4885CHRM4 4/4885PDE10A 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.