Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.47 |
| ▸ | PIM1 | P11309 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184907 | 1.00 | PIM2 (0.53) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL12391074 | 1.00 | PIM2 (0.53) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL2185190 | 0.84 | PIM1 (0.50) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL2185185 | 0.84 | PIM1 (0.50) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL2185046 | 0.84 | PIM2 (0.45) | PIM2PIM3PIM1 | |
| SCHEMBL2203185 | 0.84 | PIM2 (0.45) | PIM2PIM3PIM1 | |
| SCHEMBL2184958 | 0.80 | PIM1 (0.49) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL2184956 | 0.80 | PIM1 (0.49) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL2185217 | 0.80 | PIM2 (0.49) | PIM2PIM3PIM1KCNH2 | |
| SCHEMBL2184264 | 0.80 | PIM2 (0.49) | PIM2PIM3PIM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342190-A1 | BICYCLIC KINASE INHIBITORS | Novartis AG (CH) | 2011-07-13 | — | — | EP | claimed |
| WO-2010026121-A1 | BICYCLIC KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | claimed |
| EP-2342190-A1 | BICYCLIC KINASE INHIBITORS | Novartis AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010026121-A1 | BICYCLIC KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |