Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768079 | 0.87 | HRH3 (0.84) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL3092730 | 0.87 | HRH3 (0.52) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL12680476 | 0.80 | HRH3 (1.00) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL5926009 | 0.80 | HRH3 (0.73) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL2253179 | 0.78 | HRH3 (0.70) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL26686938 | 0.78 | HRH3 (0.70) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL5925786 | 0.78 | HRH3 (0.70) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL26353483 | 0.77 | HRH3 (0.61) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL1822450 | 0.76 | HRH3 (0.67) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL11366830 | 0.76 | HRH3 (0.67) | HRH3HDAC8HDAC6PYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020070332-A1 | OXINDOLE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | ICHNOS SCIENCES S.A. (CH) | 2020-04-09 | — | — | WO | disclosed |
| WO-2020070331-A1 | INDOLINONE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | ICHNOS SCIENCES S.A. (CH) | 2020-04-09 | — | — | WO | disclosed |