Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21919491 | 0.80 | MEN1 (0.35) | NOS3NOS1NOS2PTPN11LMNA | |
| SCHEMBL9089007 | 0.77 | GRM4 (0.36) | NOS3NOS1NOS2PTPN11GRM4 | |
| SCHEMBL795349 | 0.75 | NOS3 (0.44) | NOS3NOS1NOS2GRM4ACHE | |
| SCHEMBL12128538 | 0.75 | HTR2C (0.32) | PARP1 | |
| SCHEMBL24283716 | 0.74 | NOS3 (0.42) | NOS3NOS1NOS2GRM4ACHE | |
| SCHEMBL25771760 | 0.74 | NOS3 (0.42) | NOS3NOS1NOS2GRM4ACHE | |
| SCHEMBL19005861 | 0.74 | NOS3 (0.42) | NOS3NOS1NOS2GRM4ACHE | |
| SCHEMBL28217559 | 0.73 | GRM4 (0.47) | NOS3NOS1NOS2LMNAGRM4 | |
| SCHEMBL795850 | 0.71 | GRM4 (0.40) | NOS3NOS1NOS2GRM4ACHE | |
| SCHEMBL27549216 | 0.71 | NOS3 (0.40) | NOS3NOS1NOS2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020072656-A1 | IMIDOZOPYRIMIDINE DERIVATIVES | GILEAD SCIENCES, INC. (US) | 2020-04-09 | — | — | WO | disclosed |