Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551876 | 0.86 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL1551881 | 0.86 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL682819 | 0.83 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL659743 | 0.83 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL1552999 | 0.83 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL27497409 | 0.81 | CHRNB2 (0.46) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| Methane SCHEMBL27798790 | 0.81 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL4772964 | 0.81 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL1481686 | 0.80 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL372608 | 0.80 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112867508-B | 4-pyridylmethyl-morpholine derivatives and their use as medicaments | 勃林格殷格翰国际有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-112867508-B | 4-pyridylmethyl-morpholine derivatives and their use as medicaments | 勃林格殷格翰国际有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-112867508-B | 4-pyridylmethyl-morpholine derivatives and their use as medicaments | 勃林格殷格翰国际有限公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-3866854-B1 | 4-PYRIDINYLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INT (DE) | 2022-08-10 | — | — | EP | disclosed |
| US-11155539-B2 | 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-26 | — | — | US | disclosed |
| US-11155539-B2 | 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-26 | — | — | US | disclosed |
| US-11155539-B2 | 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-26 | — | — | US | disclosed |
| CN-112867508-A | 4-pyridylmethyl-morpholine derivatives and their use as medicaments | 勃林格殷格翰国际有限公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-112867508-A | 4-pyridylmethyl-morpholine derivatives and their use as medicaments | 勃林格殷格翰国际有限公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-112867508-A | 4-pyridylmethyl-morpholine derivatives and their use as medicaments | 勃林格殷格翰国际有限公司 | 2021-05-28 | — | — | CN | disclosed |
| US-20200123141-A1 | 4-Pyridinylmethyl-Morpholine Derivatives and the use thereof as Medicament | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-04-23 | — | — | US | disclosed |
| US-20200123141-A1 | 4-Pyridinylmethyl-Morpholine Derivatives and the use thereof as Medicament | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-04-23 | — | — | US | disclosed |
| US-20200123141-A1 | 4-Pyridinylmethyl-Morpholine Derivatives and the use thereof as Medicament | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-04-23 | — | — | US | disclosed |
| WO-2020079042-A1 | 4-PYRIDINYLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |
| WO-2020079042-A1 | 4-PYRIDINYLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155539-B2 | 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament | GRIN2A, GRIN2C, GRIN3A | SLC6A2 2044/4885SLC6A4 826/4885SLC6A3 2187/4885 |
| US-20200123141-A1 | 4-Pyridinylmethyl-Morpholine Derivatives and the use thereof as Medicament | GRIN2A, GRIN2C, GRIN3A | SLC6A2 2044/4885SLC6A4 826/4885SLC6A3 2187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.