Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 10/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21946316 | 0.86 | JAK3 (0.60) | JAK3LCKBTKSYKEGFR | |
| SCHEMBL24927487 | 0.86 | JAK3 (0.60) | JAK3LCKBTKSYKEGFR | |
| SCHEMBL21946882 | 0.86 | JAK3 (0.60) | JAK3LCKBTKSYKEGFR | |
| SCHEMBL31039916 | 0.86 | JAK3 (0.60) | JAK3LCKBTKSYKEGFR | |
| SCHEMBL21855327 | 0.86 | JAK3 (0.45) | JAK3LCKBTKALKSYK | |
| SCHEMBL18296152 | 0.85 | LCK (0.49) | JAK3LCKBTKALKEGFR | |
| SCHEMBL21855184 | 0.84 | JAK3 (0.60) | JAK3LCKBTKEGFR | |
| SCHEMBL21855180 | 0.82 | JAK3 (0.60) | JAK3LCKBTKEGFR | |
| SCHEMBL21946788 | 0.80 | JAK3 (0.50) | JAK3LCKBTKEGFR | |
| SCHEMBL21946354 | 0.79 | JAK3 (0.56) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |