Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233957 | 0.84 | ESR1 (0.44) | ESR1ESR2CHEK2LTA4HHRH4 | |
| SCHEMBL1359340 | 0.82 | ESR1 (0.61) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6004572 | 0.80 | ESR1 (0.51) | ESR1ESR2SSTR2 | |
| Hydrochloric Acid SCHEMBL6005550 | 0.79 | ESR1 (0.54) | ESR1ESR2LTA4H | |
| Hydrochloric Acid SCHEMBL6004711 | 0.78 | ESR1 (0.56) | ESR1ESR2SSTR2 | |
| Hydrochloric Acid SCHEMBL6004577 | 0.78 | ESR1 (0.50) | ESR1ESR2LTA4H | |
| Hydrochloric Acid SCHEMBL6005706 | 0.78 | ESR1 (0.54) | ESR1ESR2LTA4H | |
| Hydrochloric Acid SCHEMBL6003405 | 0.77 | ESR1 (0.66) | ESR1ESR2CHEK2SSTR2 | |
| SCHEMBL6005679 | 0.77 | CHEK2 (0.44) | ESR1ESR2CHEK2AURKBSSTR2 | |
| SCHEMBL6235937 | 0.76 | ESR1 (0.57) | ESR1ESR2LTA4HSSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342189-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF OSTEOARTHRITIS | ELI LILLY AND COMPANY (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010036497-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | ELI LILLY AND COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |
| EP-1709021-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | ELI LILLY AND COMPANY (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073204-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | ELI LILLY AND COMPANY (US) | 2005-08-11 | — | — | WO | disclosed |