Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MLNR | O43193 | 2/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856317 | 0.91 | IDH2 (0.43) | MALT1EPHX2MLNRTEAD1IDH2 | |
| SCHEMBL21856359 | 0.89 | PHGDH (0.46) | MALT1EPHX2MLNRTEAD1TEAD4 | |
| SCHEMBL21856338 | 0.89 | PHGDH (0.46) | MALT1EPHX2MLNRTEAD1TEAD4 | |
| SCHEMBL21856333 | 0.89 | PHGDH (0.46) | MALT1EPHX2MLNRTEAD1TEAD4 | |
| SCHEMBL21856302 | 0.88 | EPHX2 (0.45) | MALT1EPHX2MLNRTEAD1TEAD4 | |
| SCHEMBL21958711 | 0.80 | MALT1 (0.46) | MALT1EGFREPHX2TEAD1TEAD4 | |
| SCHEMBL21958713 | 0.73 | EGFR (0.66) | EGFREPHX2TEAD1DCUN1D1 | |
| SCHEMBL21959807 | 0.73 | IDH2 (0.47) | MALT1EPHX2MLNRTEAD1IDH2 | |
| SCHEMBL1420520 | 0.73 | MALT1 (0.66) | MALT1EPHX2IDH2LMNAALDH1A1 | |
| SCHEMBL24781682 | 0.73 | EPHX2 (0.60) | EGFREPHX2MLNRLMNAUBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |