Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 2/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856333 | 1.00 | PHGDH (0.46) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL21856338 | 1.00 | PHGDH (0.46) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL21856302 | 0.97 | EPHX2 (0.45) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL21856317 | 0.93 | IDH2 (0.43) | PHGDHKMT2AEPHX2MALT1MLNR | |
| SCHEMBL21856340 | 0.89 | MALT1 (0.43) | EPHX2LMNAMALT1MLNRTEAD1 | |
| SCHEMBL19101438 | 0.79 | PHGDH (0.52) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL21959809 | 0.78 | EPHX2 (0.50) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL21856330 | 0.78 | ROCK2 (0.52) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL15120074 | 0.77 | PHGDH (0.54) | PHGDHKMT2AEPHX2ROCK2LMNA | |
| SCHEMBL21856363 | 0.76 | SLC6A2 (0.46) | KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |