Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24781277 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL21856359 | 0.76 | PHGDH (0.46) | KMT2AEPHX2 | |
| SCHEMBL21856333 | 0.76 | PHGDH (0.46) | KMT2AEPHX2 | |
| SCHEMBL21856338 | 0.76 | PHGDH (0.46) | KMT2AEPHX2 | |
| Hydrochloric Acid SCHEMBL1010066 | 0.74 | TP53 (0.53) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL24168852 | 0.74 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL21959041 | 0.74 | EPHX2 (0.47) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL21958740 | 0.74 | TEAD1 (0.53) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL21957473 | 0.74 | EPHX2 (0.47) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL21856302 | 0.73 | EPHX2 (0.45) | KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |