Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB2 | O60825 | 11/20 | 1.00 |
| ▸ | PFKFB3 | Q16875 | 11/20 | 1.00 |
| ▸ | PFKFB1 | P16118 | 11/20 | 1.00 |
| ▸ | AS3MT | Q9HBK9 | 7/20 | 0.76 |
| ▸ | NSD2 | O96028 | 3/20 | 0.76 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.76 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RNF4 | P78317 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856721 | 0.87 | PFKFB2 (1.00) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL21856750 | 0.84 | PFKFB1 (1.00) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL21856678 | 0.83 | PFKFB1 (1.00) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL21856686 | 0.82 | PFKFB1 (1.00) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL5857288 | 0.72 | PFKFB2 (1.00) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL11645364 | 0.71 | RNF4 (0.71) | LTA4HRECQLRNF4 | |
| SCHEMBL11642720 | 0.71 | PFKFB2 (0.60) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL21856792 | 0.70 | PFKFB3 (1.00) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL11645090 | 0.70 | KMT2A (0.71) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 | |
| SCHEMBL5857169 | 0.69 | AS3MT (0.66) | PFKFB2PFKFB3PFKFB1AS3MTNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | claimed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | claimed |
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |