PFKFB1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21856681	1.00	19/20
SCHEMBL21856704	1.00	19/20
SCHEMBL21856728	1.00	19/20
SCHEMBL21856730	1.00	19/20
SCHEMBL21856749	1.00	19/20
SCHEMBL21856756	1.00	19/20
SCHEMBL21856777	1.00	19/20
SCHEMBL21856778	1.00	19/20
SCHEMBL21856796	1.00	19/20
SCHEMBL21856800	1.00	19/20
SCHEMBL21856810	1.00	19/20
SCHEMBL21856820	1.00	19/20
SCHEMBL21856828	1.00	19/20
SCHEMBL21856832	1.00	19/20
SCHEMBL21856838	1.00	19/20
SCHEMBL21857526	1.00	19/20
SCHEMBL21857976	0.62	19/20
SCHEMBL10097296	0.55	19/20
SCHEMBL10095374	0.53	19/20
SCHEMBL21856712	1.00	18/20

Clinical trials — most relevant to PFKFB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Ketohexokinase Inhibition in NAFLD	PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome	PHASE2	COMPLETED
Dynamic PET/CT Evaluated the Response of Neoadjuvant Anti-PD1 Combination With Chemotherapy for Ⅱa-Ⅲb NSCLC	PHASE2	UNKNOWN
Safety, Efficacy Evaluation of Empagliflozin Administration for Neutropenia in Glycogenosis Type 1b and G6PC3 Deficiency	PHASE2	UNKNOWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Evaluation Of Striatal Glucose Metabolism With Positron Emission Tomography Following PF-02545920 In Healthy Subjects	PHASE1	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
Effect of Acute Fructose Load in Human	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours	nan	RECRUITING
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
Signaling Pathways Targeting Colorectal Cancer in Egypt	nan	COMPLETED
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology	nan	COMPLETED
Early Versus Late FDG-PET/CT in Bladder Cancer	nan	COMPLETED
Circadian Brown Adipose Tissue Metabolism	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
Dual PETOvac - Dual Time PET/CT in the Preoperative Assessment of Ovarian Cancer	nan	UNKNOWN
METabolic PROFILE of Hepatocarcinoma and Pancreatic Tumors	nan	RECRUITING
Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors	nan	UNKNOWN
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients	nan	UNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)	nan	NOT_YET_RECRUITING
Choline PET/CT vs. Dual Time Point FDG PET/CT in Prostate Cancer	nan	COMPLETED
Diagnostic Significance of Single Center, Open and Prospective Evaluation of 18F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesions and Differentiating Multiple Primary Lung Cancer From Intrapulmonary Metastases of Non-small Cell Lung Cancer	nan	UNKNOWN
Diagnostic Significance of Single Center, Open and Prospective Evaluation of 18F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesions of Primary Hepatocellular Carcinoma	nan	WITHDRAWN
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia	nan	UNKNOWN
Early Response Assessment of Induction Chemotherapy in Acute Myeloid Leukemia Patients Using F-18 FLT PET/CT	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PFKFB1 binder may also engage these)

Protein	Name	Similarity
P70266	—	1.000	P70266 →
P49872	—	1.000	P49872 →
Q4R8B6	—	1.000	Q4R8B6 →
P07953	—	1.000	P07953 →
Q6DTY7	—	0.999	Q6DTY7 →
P25114	—	0.998	P25114 →
PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	0.997	landscape →
PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4	0.997	landscape →
Q91309	—	0.996	Q91309 →
Q28901	—	0.996	Q28901 →
P70265	—	0.996	P70265 →
P26285	—	0.995	P26285 →
O35552	—	0.995	O35552 →
Q91348	—	0.994	Q91348 →
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.994	landscape →
Q9JJH5	—	0.993	Q9JJH5 →
Q5R9C1	—	0.992	Q5R9C1 →
P32604	—	0.989	P32604 →
Q21122	—	0.989	Q21122 →
Q5NVT1	—	0.989	Q5NVT1 →
Q9URZ7	—	0.983	Q9URZ7 →
Q91YL3	—	0.983	Q91YL3 →
Q8VYB2	—	0.981	Q8VYB2 →
Q6DNF7	—	0.980	Q6DNF7 →
Q9FKS0	—	0.980	Q9FKS0 →
O65583	—	0.980	O65583 →
Q9LK34	—	0.980	Q9LK34 →
Q9LTY6	—	0.980	Q9LTY6 →
Q55EL3	—	0.979	Q55EL3 →
Q9NWZ5	—	0.979	Q9NWZ5 →