Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 12/20 | 0.84 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.83 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.72 |
| ▸ | ACLY | P53396 | 3/20 | 0.66 |
| ▸ | CPT2 | P23786 | 1/20 | 0.62 |
| ▸ | CPT1A | P50416 | 1/20 | 0.62 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856914 | 0.91 | PFKFB3 (1.00) | PFKFB3PFKFB4LNPEPACLYCPT2 | |
| SCHEMBL21857884 | 0.91 | PFKFB4 (1.00) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL21857695 | 0.90 | PFKFB3 (0.88) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL21857018 | 0.89 | PFKFB4 (0.83) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL21857509 | 0.89 | PFKFB3 (1.00) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL21857467 | 0.86 | PFKFB3 (1.00) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL21857394 | 0.86 | PFKFB3 (1.00) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL21857003 | 0.86 | PFKFB3 (1.00) | PFKFB3PFKFB4LNPEP | |
| SCHEMBL21857061 | 0.85 | PFKFB3 (1.00) | PFKFB3PFKFB4LNPEPACLY | |
| SCHEMBL28646098 | 0.81 | PFKFB3 (0.76) | PFKFB3PFKFB4LNPEPACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |