PFKFB4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL787754	1.00	14/20
SCHEMBL788108	1.00	14/20
SCHEMBL793576	0.60	13/20
SCHEMBL787865	1.00	12/20
SCHEMBL787888	1.00	12/20
SCHEMBL787986	1.00	12/20
SCHEMBL788033	1.00	12/20
SCHEMBL788169	1.00	12/20
SCHEMBL788343	1.00	12/20
SCHEMBL788157	0.80	12/20
SCHEMBL788203	0.77	12/20
SCHEMBL788469	0.77	12/20
SCHEMBL787664	0.76	12/20
SCHEMBL787908	0.74	12/20
SCHEMBL788594	0.74	12/20
SCHEMBL787889	0.72	12/20
SCHEMBL788755	0.68	12/20
SCHEMBL787869	1.00	11/20
SCHEMBL788058	1.00	11/20
SCHEMBL788791	0.90	11/20

Clinical trials — most relevant to PFKFB4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
Ketohexokinase Inhibition in NAFLD	PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome	PHASE2	COMPLETED
Dynamic PET/CT Evaluated the Response of Neoadjuvant Anti-PD1 Combination With Chemotherapy for Ⅱa-Ⅲb NSCLC	PHASE2	UNKNOWN
A Phase 2 Trial of SCO-101 in Combination With FOLFIRI for Patients With Metastatic Colorectal Cancer (mCRC) With Acquired Resistance to FOLFIRI	PHASE1/PHASE2	UNKNOWN
Safety, Efficacy Evaluation of Empagliflozin Administration for Neutropenia in Glycogenosis Type 1b and G6PC3 Deficiency	PHASE2	UNKNOWN
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Chinese Herbal Formulation PHY906 and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer	PHASE1	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
A Dose-Finding Study of AG-348 in Sickle Cell Disease	EARLY_PHASE1	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
Effect of Acute Fructose Load in Human	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours	nan	RECRUITING
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology	nan	COMPLETED
Early Versus Late FDG-PET/CT in Bladder Cancer	nan	COMPLETED
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Thyroid Cancer and (FDG)PET/CT Scan	nan	UNKNOWN
Dual PETOvac - Dual Time PET/CT in the Preoperative Assessment of Ovarian Cancer	nan	UNKNOWN
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients	nan	UNKNOWN
METabolic PROFILE of Hepatocarcinoma and Pancreatic Tumors	nan	RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment	nan	UNKNOWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)	nan	NOT_YET_RECRUITING
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia	nan	UNKNOWN
Circadian Brown Adipose Tissue Metabolism	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PFKFB4 binder may also engage these)

Protein	Name	Similarity
Q4R8B6	—	1.000	Q4R8B6 →
P25114	—	1.000	P25114 →
Q6DTY7	—	1.000	Q6DTY7 →
P70266	—	1.000	P70266 →
P49872	—	1.000	P49872 →
PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	1.000	landscape →
P07953	—	1.000	P07953 →
Q28901	—	1.000	Q28901 →
P70265	—	1.000	P70265 →
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	1.000	landscape →
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1	1.000	landscape →
Q91348	—	1.000	Q91348 →
Q91309	—	1.000	Q91309 →
Q9JJH5	—	0.999	Q9JJH5 →
Q5R9C1	—	0.998	Q5R9C1 →
Q21122	—	0.998	Q21122 →
P26285	—	0.997	P26285 →
O35552	—	0.996	O35552 →
P32604	—	0.996	P32604 →
Q5NVT1	—	0.996	Q5NVT1 →
Q8VYB2	—	0.989	Q8VYB2 →
Q9URZ7	—	0.988	Q9URZ7 →
O65583	—	0.988	O65583 →
Q9NWZ5	—	0.988	Q9NWZ5 →
Q9LK34	—	0.986	Q9LK34 →
Q55EL3	—	0.985	Q55EL3 →
Q91YL3	—	0.985	Q91YL3 →
Q9LTY6	—	0.985	Q9LTY6 →
Q5RAZ4	—	0.985	Q5RAZ4 →
Q9UTC5	—	0.985	Q9UTC5 →