Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 0.51 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187763 | 0.94 | TSHR (0.51) | TSHRLMNAHSD17B10KDM4EESR1 | |
| SCHEMBL2187509 | 0.92 | LMNA (0.57) | TSHRLMNAHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL2187921 | 0.87 | SMN1; SMN2 (0.52) | TSHRLMNAHSD17B10KDM4EESR1 | |
| SCHEMBL2187194 | 0.86 | TSHR (0.49) | TSHRLMNAHSD17B10KDM4EESR1 | |
| SCHEMBL2188053 | 0.85 | TSHR (0.52) | TSHRLMNAHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL2186962 | 0.84 | LMNA (0.56) | TSHRLMNAHSD17B10SMN1; SMN2GAA | |
| SCHEMBL2186627 | 0.84 | LMNA (0.49) | TSHRLMNAHSD17B10KDM4EESR1 | |
| SCHEMBL2185672 | 0.84 | LMNA (0.53) | TSHRLMNAHSD17B10SMN1; SMN2GAA | |
| SCHEMBL2186442 | 0.84 | LMNA (0.58) | TSHRLMNAHSD17B10KDM4EESR1 | |
| SCHEMBL2188250 | 0.83 | LMNA (0.51) | TSHRLMNAHSD17B10GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |